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. 2022 Jan 3;14:801882. doi: 10.3389/fnmol.2021.801882

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Copyright © 2022 Becic, Leifeld, Shaukat and Hollmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Superposition of selected tetraspanin structures with the predicted structure of Tspan6. The left side shows the superposition of the structures of Tspan6 (blue) and Tspan7 (gray) predicted by AlphaFold; both tetraspanins are known to influence glutamatergic synapses. For comparison, the overlays of the structure of Tspan6 with already known resolved structures of tetraspanins are shown on the right (from left to right): overlay of Tspan6 with Tspan25 (yellow) (PDB model 6WVG) as well as with Tspan28 (pale pink) (PDB model 5TCX), and with Tspan29 (orange) (PDB model 6K4J).