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. 2022 Jan 3;12:791780. doi: 10.3389/fimmu.2021.791780

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Copyright © 2022 Gong, Liu, Liu, Li, Guo, Zhou and Hong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between dysregulated cytokines and differential genera in anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. (A–I) Analysis of 12 immune cytokines in patients with NMDAR encephalitis and in healthy controls (HCs). Participants’ sera were run on Luminex. Differences are determined by a t-test. (J) Correlation analyses of cytokines and differentially enriched genera between any two groups. Abundance rates of differentially enriched species (top 30) in HCs and NMDAR encephalitis were evaluated for association with differential immune factors using Spearman’s correlation analysis. Correlations are shown by color gradients from green (negatively correlated) to purple (positively correlated). Correlation coefficients and p-values (*p < 0.05, **p < 0.01, ***p < 0.001, **** p < 0.0001) are shown.