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The adverse events in the endostar combined with chemotherapy.
| Adverse Event | Grade1 | Grade 2 | Grade 3 | Grade 4 | Total |
|---|---|---|---|---|---|
| myelosuppression | 35 | 11 | 4 | 7 | 57 (57/221, 25.8%) |
| gastrointestinal reactions | 53 | 1 | 1 | 0 | 55 (55/221, 24.9%) |
| allergies | 9 | 1 | 1 | 0 | 11 (11/221, 5%) |
| pigmentation | 14 | 7 | 0 | 0 | 21 (21/221, 9.5%) |
| abnormal liver function | 46 | 5 | 0 | 0 | 51 (51/221, 23.1%) |
| arrhythmia | 17 | 3 | 0 | 0 | 20 (20/221, 9%) |
| renal inadequacy | 3 | 3 | 0 | 0 | 6 (6/221, 2.7%) |
| Total | 177 | 31 | 6 | 7 | 221 |
