Figure 2.
Distinct gut microbiome in different groups. (A,B) Phylum-level and genus-level composition of gut microbiome in patients with CHD-NAFLD, patients with CHD, and healthy controls (HC). (C) Differential bacteria at class-level between CHD-NAFLD group and CHD group. (D) Species-level alterations in gut microbiome in CHD-NAFLD, CHD, HC groups. Stars are marked for significant enrichment or depletion either in the CHD-NAFLD group, CHD group, or in the HC group. (E) The summed relative abundances of gut microbes were compared between the CHD-NAFLD and CHD groups based on species-level. (F) Spearman correlation between key gut microbiomes and altered serum metabolites. Red font: gut microbiomes enriched in CHD-NAFLD. Black font: gut microbiomes depleted in CHD-NAFLD. Pink font: serum metabolites enriched in CHD-NAFLD. Green font: serum metabolites depleted in CHD-NAFLD. *P < 0.05, **P < 0.01.