Table 3.
Diagnostic performance and accuracy of CT-FFR across CACs categories on per-patient and per-vessel level.
| N | CAC score | Accuracy | Sensitivity | Specificity | PPV | NPV | AUC | |
|---|---|---|---|---|---|---|---|---|
| Per-patient level | ||||||||
| 0 | 46 | 0 | 89.1 (78.3–97.8) | 83.33 (58.6–96.4) | 92.86 (76.5–99.1) | 88.2 (66.0–96.7) | 89.7 (75.4–96.1) | 0.88 (0.75–0.96) |
| > 0 to <100 | 114 | 36.35 (1–99) | 85.1 (78.1–91.2) | 82.26 (70.5–90.8) | 88.46 (76.6–95.6) | 89.5 (79.9–94.8) | 80.7 (70.8–87.8) | 0.85 (0.78–0.91) |
| ≥ 100 to <400 | 84 | 216 (100–395) | 90.5 (83.3–96.4) | 92.11 (78.6–98.3) | 87.13 (76.4–96.4) | 87.5 (75.3–94.2) | 93.2 (82.1–97.6) | 0.91 (0.82–0.96) |
| ≥ 400 | 61 | 630.5 (423.2–2895.0) | 93.4 (86.9–98.4) | 97.30 (85.8–99.9) | 87.50 (67.6–97.3) | 92.3 (80.6–97.2) | 95.5 (75.1–99.3) | 0.92 (0.83–0.98) |
| P | – | – | 0.368 | 0.107 | 0.902 | 0.913 | 0.152 | all p > 0.0.5 |
| Per-vessel level | ||||||||
| 0 | 77 | 0 | 81.8 (74.0–90.0) | 81.48 (61.9–93.7) | 82.0 (68.6–91.4) | 71.0 (56.8–81.9) | 89.1 (78.6–94.8) | 0.82 (0.71–0.89) |
| > 0 to <100 | 149 | 29(0.1–99.7) | 88.6 (83.2–93.3) | 86.3 (76.2–93.2) | 92.11 (83.6–97.0) | 91.3 (82.9–85.8) | 87.5 (79.7–92.6) | 0.94 (0.89–0.97) |
| ≥ 100 to <400 | 97 | 207.0 (102.5–394.9) | 86.6 (79.4–92.8) | 93.62 (82.5–98.7) | 82.0 (68.6–91.4) | 83.0 (72.9–89.9) | 93.2 (81.9–97.6) | 0.89 (0.81–0.94) |
| ≥ 400 | 25 | 713.86 (403.2–2012.6) | 96.0 (88.0–100) | 93.33 (68.1–99.8) | 100.0 (69.2–100.0) | 100 | 90.0 (60.1–98.5) | 0.98 (0.84–1.00) |
| P | – | – | 0.213 | 0.089 | 0.063 | 0.043 | 0.769 | all p > 0.0.5 |
CT-FFR, CT derived fractional flow reserve; CAC, coronary artery calcium; PPV, positive predictive value; NPV, negative predictive value; AUC, area of receiver operating characteristic curve. CAC score: median(range). Accuracy, sensitivity, specificity, PPV, NPV: % (95% confidence interval). AUC: value (95% confidence interval).