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. 2021 Feb 17;71(2):254–264. doi: 10.1136/gutjnl-2020-323608

Figure 2.

Figure 2

Post-hoc analysis of change in haemoglobin A1c (HbA1c) levels and liver MRI proton density fat fraction (MRI-PDFF) stratified by baseline fasting plasma glucose (FPG) level status (per-protocol (PP) populations). Median HbA1c per cent change from baseline to 24 weeks (duodenal mucosal resurfacing (DMR) versus sham procedure) in the overall (A), European (C) and Brazilian (E) PP patients with baseline FPG ≥10 mmol/L compared with patients with baseline FPG <10 mmol/L. In patients with baseline liver MRI-PDFF >5%, median liver MRI-PDFF per cent change from baseline to 12 weeks (DMR vs sham procedure) in the overall (B), European (D), and Brazilian (F) PP patients with baseline FPG ≥10 mmol/L compared with FPG <10 mmol/L. Treatment comparison of one-sided p value based on analysis of covariance model with multiple imputation on the rank values (modified ridit scores). Via multiple imputation, analysis is based on all patients in the population of interest. The overall PP population includes patients from both European and Brazilian study sites. The European PP population consists of patients from Italy, UK, Belgium and Netherlands.