Table 5.

GRADE-CERQual summary of review findings

Summary of review finding	Studies contributing to the finding	GRADE-CERQual assessment of confidence in the evidence
Individuals at-risk of RA have gained knowledge of RA through experiencing symptoms or witnessing the impact of RA on their relatives	29–34	Moderate confidence
Individuals at-risk of RA identified a need for more knowledge about RA and risk factors.	30–32 34	High confidence
Individuals at-risk of RA perceived that certain factors increase the risk of developing RA.	29–32	Moderate confidence
Individuals at-risk of RA acknowledged that preventive interventions have a role in modifying risk.	28–30 32 34	Moderate confidence
Individuals at-risk of RA identified that engagement with a preventive intervention would be influenced by its effectiveness in reducing risk.	30 32 34	Low confidence
Having symptoms would make individuals at-risk of RA more willing to consider preventive interventions.	28–30 34	Moderate confidence
Seeing the impact of RA on a relative would make individuals at-risk of RA more willing to consider preventive interventions.	29 30 34	Moderate confidence
Individuals at-risk of RA had concerns about taking preventive medication.	28–30 32 34	Moderate confidence
Individuals at-risk of RA highlighted a need for more information about their actual risk and preventive interventions before engaging.	28–30 32 34	Moderate confidence
Individuals at-risk of RA perceived predictive testing as useful.	28 30–33	Moderate confidence
Presence of symptoms, perceived effectiveness and understanding of the impact of disease affect individuals’ decision to undergo predictive testing.	28 31	Low confidence
Individuals at-risk of RA had concerns about predictive testing.	28 31–33	Moderate confidence

GRADE-CERQual, Grading of Recommendations Assessment, Development and Evaluation–Confidence in Evidence from Reviews of Qualitative Research; RA, rheumatoid arthritis.