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. 2021 Oct 8;81(1):56–67. doi: 10.1136/annrheumdis-2021-220308

Figure 3.

Figure 3

The splicing machinery is deeply altered in the joints of both patients with RA and RA mouse model. (A) Schematic representation of the analysis of the spliceosome signature in paired samples of RA PBMC from peripheral blood and synovial fluid. (B) Violin plots representing the expression levels of the spliceosome signature in PBMC of 15 patients with RA. (C) Schematic representation of the analysis of spliceosome signature in paired samples of whole blood and synovial tissue from patients with RA using public RNA-seq data set (E-MTAB-6141). (D) Violin plots representing the expression levels of the spliceosome signature in 44 patients with RA. (E) Schematic representation of the analysis of the spliceosome machinery in joints from K/BxN arthritis mouse model. (F) Violin plots representing the expression levels of the mouse spliceosome machinery components. *p<0.05, **p<0.01. HD, healthy donors; PB, peripheral blood; PBMC, peripheral blood mononuclear cells; RA, rheumatoid arthritis; SF, synovial fluid; ST, synovial tissue; WB, whole blood.