Figure 1.

Apigenin exhibits robust metabolic protective effects in HFD-fed mice.

C57BL/6 J male mice were randomly divided into four groups. (A) ND and HFD fed mice were treated daily with vehicle or Api (50 mg/kg) for 16 weeks by oral gavage. (B) Body weight for the above four groups of mice. (C) Body weight gain. (D) Average daily food intake. (E,F) Liver weight and Liver weight/Body weight ratio. (G,H) TG and TC contents in liver. Serum levels of (I) TG, (J) TC, (K) LDL-c, and (L) HDL-c were determined. (M) GTT results and area under the curve of GTT. (N) ITT results and area under the curve of ITT. Error bars are expressed as means ± SEM (n = 6). Statistical significance was determined by one-way ANOVA with Tukey tests for multiple-group comparisons. ^*p < 0.05, ^**p < 0.01, and ^***p < 0.001 vs. ND ^#p < 0.05 ^##p < 0.01, and ^###p < 0.001 vs. HFD.