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. 2022 Jan 3;8:799060. doi: 10.3389/fmolb.2021.799060

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Copyright © 2022 Chen, Liu, Ning, Wei, Li, Wei and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ROC curve analyses in 49 mCRC and 41 pCRC patients. miR-96, miR-99b, CEA and miR-96/miR-99b have satisfactory diagnostic value for mCRC patients. Among them, miR-96/miR-99b is the most powerful combination indicator in our study, with AUC = 0.91.