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. 2022 Jan 3;12:778190. doi: 10.3389/fmicb.2021.778190

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Copyright © 2022 Bao, Xie, Ma, An, Gu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Integration analysis of proteome and transcriptome. (A) The profile of differentially transcribed genes (DEGs) and differentially expressed proteins (DEPs) of cefiderocol-treated strains compared with the WT strains. (B) The classification of DEGs and DEPs. (C) Comparison of the number of identified transcripts and proteins. (D) Venn diagram of the number of DEPs and DEGs in proteomics and transcriptome. (E) Scatter plot of genes and its corresponding proteins expression in cefiderocol-treated strains vs. the WT strains. BU, transcript level and protein level both up-regulated. PUTD, transcript level down-regulated and protein level up-regulated. TU, transcript level up-regulated and protein level not regulated. PU, transcript level normal and protein level up-regulated. PDTU, transcript level up-regulated and protein level down-regulated. BD, transcript level and protein level both down-regulated. TD, transcript level down-regulated and protein level not regulated. PD, transcript level normal and protein level down-regulated. PR, proteomics. TR, transcriptomics.