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Chemical structures of KIR-based SOCS1 proteomimetics. Green represents non-native residues in PS5 upon combinatorial modifications (Cys(Acm) and Gln), blue represents the residue is alternatively Ser60 in PS5 and Lys in internal cycles PS5 for the formation of lactam bridge (with Asp52), and red represents the aromatic residue Nal1 or Phe56.
