TABLE 3.
SOCS3 proteomimetics: name, sequence, length, and dissociation constants values (µM) toward JAK2 catalytic domain.
| Name | Sequence | Length | KD (µM) |
|---|---|---|---|
| KIR | 22LKTFSSKSEYQL33 | 12 | 360 a |
| ESS | 34VVNAVRKLQESG45 | 12 | >>1,000 a |
| KIRESS | 22LKTFSSKSEYQLVVNAVRKLQESG45 | 24 | 6.43 a |
| ESSCONG | 34VVNAVRKLQESGFYWSAVT52 | 19 | No binding |
| restKIRESSCONG | 25FSSKSEYQLVVNAVRKLQESGFYWSAVT52 | 28 | No binding |
| KIRCONG chim | KβAla25FSSKSEYQL33βAlaβAla46FYWSAVT52 | 20 | 11.0 b |
SPR (La Manna et al., 2018b).
MST (La Manna et al., 2020a).