TABLE 2.

Outline of studies about the function of miR-1246 in animal models (∆: knock-down or deletion, PDX: derived orthotopic xenograft, NOD-SCID: non-obese diabetic/severe combined immunodeficiency, NSG: NOD Cg-Prkdcscid Il2rgtm1Wjl/SzJ).

Tumor type	Animal models	Results	References
Colorectal cancer	Male BALB/c nude mice	∆ METTL3: ↓ metastasis	Peng et al. (2019)
	BALB/c nude mice	∆ miR-1246 in Fn-Ex group: ↓ metastasis	Guo et al. (2021)
Lung cancer	Female BALB/c nude mice	∆ METTL3: ↓ tumor volume, ↓ tumor weight	Huang et al. (2021)
		↑ miR-1246: ↑ tumor volume, ↑ tumor weight
Cervical cancer	Athymic BALB/c nude mice	∆ miR-1246: ↓ tumor volume, ↓ tumor growth	Du et al. (2019)
Prostate cancer	Nude mice	↑ miR-1246 in xenograft tissues: ↓ tumor growth	Bhagirath et al. (2018)
Breast cancer	Plasma of a PDX mouse	miR-1246 was higher in the plasma exosomes of patient-PDX mice compared to control mice	Hannafon et al. (2016)
Hepatocellular carcinoma	Male BALB/c-nu/nu mice	↑ miR-1246: ↑ tumor growth, ↑ metastasis	Huang et al. (2020a)
	Male BALB/c nude or NOD-SCID mice	∆ miR-1246: ↓ tumor initiation, ↓ tumor volume, ↓ metastasis	Chai et al. (2016)
	Female athymic BALB/c-nu/nu mice	↑ galectin-9: ↓ tumor growth of Li-7 cells, ↑ apoptosis, ↑ miR-1246	Fujita et al. (2015)
Oral squamous cell carcinoma	BALB/c nude mice	∆ miR-1246: ↓ tumor size	Lin et al. (2018)
		↑ miR-1246: ↑ tumor growth
Glioma	Male nude mice	↑ miR-1246: ↑ proliferation, ↑ M2 macrophage polarization	Qian et al. (2020)
Pancreatic cancer	Female non-obese mice with diabetes/severe combined immunodeficiency	↑ miR-1246 in Panc1-P-l-OE: ↑ tumourigenicity	Hasegawa et al. (2014)
Ovarian cancer	Nude mice	∆ miR-1246 + chemotherapy: ↓ tumor weight, ↓ macrophages recruited by tumors	Kanlikilicer et al. (2018)
Acute myeloid leukemia (AML)	NOD/SCID mice	↓ EVs-miR-1246: ↓ tumor volume, ↓ tumor weight	Chen et al. (2021a)
	NSG and C57BL/6J mice	↑ miR-1246: ↑ quiescence	Abdelhamed et al. (2019)
Leukemia	Male BALB/c nude mice	∆ miR-1246: ↓ tumor volume, ↓ tumor weight, ↓ chemotherapy resistance	Xie et al. (2021)