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. 2022 Jan 3;12:723784. doi: 10.3389/fphar.2021.723784

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Copyright © 2022 Peng, You, Yang, Wang, Liu, Yin, Xu, Dong, Yin and Ni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of ginsenoside Rb1 on MMP in HL-7702 cells treated with TP. (A) Changes in MMP in the cells after treatment with TP and ginsenoside Rb1, as measured using JC-1 staining. JC-1 is a mitochondria-specific lipophilic cationic fluorescence dye able to selectively enter the mitochondria. When the mitochondrial membrane potential decreased, JC-1 transferred from the mitochondria to the cytoplasm, and the fluorescence changed from red to green. (B) Histogram of average JC-1 fluorescence in cells. (C) Effect of TP and ginsenoside Rb1 on the quantity of cytochrome c in the cytosol and mitochondria, as determined using Western blotting, with β-actin and COX IV as loading controls (cytosolic and mitochondrial, respectively). Data are expressed as mean ± S.D, n = 3. (*p < 0.05 vs. untreated cells in control group; ^# p < 0.05 vs. TP-only group).