Table 4.

The potency of some bee products against wounds clinically.

Condition or Disease	Recruitment status	Bee product/Form/Doses	Inclusion Criteria	Type of the study/ Clinical trials phase/No of participants	Mode of action	References
Malignant wounds	Completed	Honey product/alginate wound dressing/Honey product dressing/Not reported	Eligible age: > 18 years Eligible gender: Male and female Patient with cancer wounds > 2 cm/ Patients take anti-neoplasm cure	Interventional/Phase 3/70 P	Enhances wound healing by reducing the size, pain and healing of wounds	(126)
Diabetic foot ulcer (T2DM)	Completed	Honey/gel sheet wound dressing/Honey gel sheet, applied on ulcer daily, for 12 weeks	Eligible age: 40 to 85 years Eligible gender: Male and female Ulcer size: ≥ 1 cm Ulcer without or with mild infection. Ulcers should be at or below malleolar region of the foot. Patients with no expected surgery within 12 weeks of administration	Interventional/Phase, not applicable/31 P	Reducing ulcer size. Decreasing level of wound fluid concentration of MMP9, TNF-α and IL-1α among groups, P < 0.05 for all tests.	(127)
Diabetic foot ulcer	Terminated	Royal jelly and panthenol (PedyPhar® Ointment)/PedyPhar, 3–5 mm was distributed on a dressing and then apply the dressing to the ulcer until the complete healing.	Eligible age: 18 to 75 years Eligible gender: Male and female/ Type 1 or type 2 diabetes mellitus with diabetic foot ulcer	Interventional/Phase 3/47 P	Reduction of the necrotic tissue resulted in enhancement of healing rate.	(128)
Wounds ulcer	Terminated	Leptospermum honey (Medi honey®)/Gel/Medihoney applied daily, for 90 days	Eligible age: > 18 years Eligible gender: Male and female Necrotic tissue ≥ 50 % in wound and surface area > 1 cm2 to <64 cm2 For diabetes HbA1c <12.0%. Pre-albumin > 16 mg/dl within the period of study	Interventional/Phase, not applicable/10 P	Reduction of necrotic tissue in wounds. Promoting the tissue proliferation.	(129)
Diabetes mellitus amputation wound and toe wound	Recruiting	Honey/MelectisG wound dressing/Honey Melectis G [honey (99.8%) and hyaluronic acid (0.2%)], until complete healing (12 months maximum).	Eligible age: > 18 years Eligible gender: Male and female Diabetic patients who have one or more amputated toes, four days before inclusion in the study. Patients to write the consent form.	Interventional/Phase, not applicable/50 P	Not reported	(130)
Palatal wound healing	Completed	0.05 cm3 of honey per 1cm of laceration, given every predetermined wound care schedule	Eligible age 10–60 years Eligible gender: Male and female	Interventional/Phase, 3/35 P	Not reported	(131)
Diabetic wound	Not yet recruiting	Honey	Eligible age: 18–70 years Eligible gender: Male and female	Interventional/Phase, not applicable/76 P	Wound size reduction.	(132)
Wound healing	Completed	Honey	Eligible age: 18–100 years Eligible gender: Male and female	Interventional/Phase, not applicable/40 P	Within 6 months after vascular surgery, the healing rate of acute or chronic surgical wounds.	(133)
Necrotizing fascitis wounds	Recruiting	Topical honey to be used for dressing 4 mL per square inch.	Eligible age: 18–70 years Eligible gender: Male and female	Interventional/ Phase, not applicable/ 326 P	Early wound healing. Decreased hospital stay.	(134)
Wound healing	Completed	ziziphus honey	Eligible age: 18–40 years Eligible gender: Male and female	Interventional/Phase, 3/30 P	Not reported	(135)
Pressure ulcer	Recruiting	Aloe and propolis applied	Eligible age: 18 Years and older Eligible gender: Male and female	Interventional/Phase, not applicable/66 P	Not reported	(136)
Burn wound	Completed	Propolis	Eligible age: 8 to 12 Weeks Eligible gender: Male and female	Interventional/ Phase, not applicable/36 P	Not reported	(137)
Wound healing	Recruiting	New Mexico Honey	Eligible age: 16-75 years Eligible gender: Male and female	Interventional/Phase, 2/ 60 P	Not reported	(138)
Leg ulcer	Completed	Honey and ionic silver dressing	Eligible age: 18 Years and older Eligible gender: Male and female	Interventional/Phase, 2/30 P	Granulation and/or epithelial tissue progression as observed	(139)
Wound healing	Recruiting	Novel biomaterial containing gelatin, manuka honey, and hydroxyapatite	Eligible age: 18 Years and older Eligible gender: Male and female	Interventional/Phase, not applicable/80 P	Not reported	(140)
Split-skin grafted third-degree burn wound	Recruiting	Manuka-Honey	Eligible age: 18 Years and older Eligible gender: Male and female	Interventional/Phase, not applicable/20 P	Not reported	(141)