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. 2022 Jan 3;12:792932. doi: 10.3389/fphar.2021.792932

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Copyright © 2022 Que, Wu, Chen, Zhang, You, Lin, Zhao, Liu, Qiu and Cheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The anti-NPP effect of koumine in sciatic nerve chronic constriction injury rats. (A) The time course of the effect of koumine on the thermal withdrawal latency. (B) The time course of the effect of koumine on the mechanical withdrawal threshold. The data are presented as the mean ± SD (n = 6) and were analyzed using two-way repeated analysis of variance (ANOVA) followed by Bonferroni’s post hoc test, ^## p < 0.01 compared with the sham control group; ^** p < 0.01 compared with the vehicle control group. KM, koumine.