FIGURE 4.
Rb2 increased the collagen content in plaque in mice. (A) Representative image of Masson's trichrome staining and quantification of the percentage of collagen (of the total lesion area) in the thoracic aorta from the Ad-NC group, Ad-miR-216a group, Ad-NC + Rb2 group, and Ad-miR-216a + Rb2 group. (B) Representative image and of quantification immunohistochemistry staining of MMP-9 in the thoracic aorta from the Ad-NC group, Ad-miR-216a group, Ad-NC + Rb2 group, and Ad-miR-216a + Rb2 group. *p < 0.05, compared to the Ad-NC group. # p < 0.05, compared to the Ad-miR-216a group. n = 5 for each group. Scale bar = 200 μM or 50 μM.