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. 2022 Jan 3;12:750261. doi: 10.3389/fendo.2021.750261

Figure 1.

Figure 1

The metabolic phenotypes of Mir221/222flox/y and Mir221/222AdipoKO male mice fed with high fat high sucrose (HFHS) or standard (STD) chow. (A) Body weight of Mir221/222flox/y and Mir221/222AdipoKO mice fed with HFHS (n=7) or STD chow (n=6), respectively. (B) Tissue weight of Mir221/222flox/y and Mir221/222AdipoKO mice fed with HFHS or STD chow at 24 weeks of age. (Epi, epididymal; Mes, mesenteric; Sub, inguinal; Brown, Brown adipose tissues) (C) Adipocyte area in epididymal adipose tissues of Mir221/222flox/y (n=3) and Mir221/222AdipoKO (n=5) mice fed with HFHS or STD. Quantitative analyses were carried out on PAS-stained paraffin sections. (D) Insulin tolerance test (ITT) in Mir221/222flox/y (n=7) and Mir221/222AdipoKO (n=6). Glucose tolerance test (GTT) in Mir221/222flox/y fed with HFHS (n=13) or STD chow (n=7) and Mir221/222AdipoKO fed with HFHS (n=16) or STD chow (n=6). Data shown as mean ± SD and analyzed by one-way ANOVA with Tukey test in (A, B), and Mann-Whitney’s U test in (C, D) (*p<0.05; **p<0.01; ***p<0.001; ****p<0.0001).