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. 2022 Jan 3;12:750261. doi: 10.3389/fendo.2021.750261

Figure 2.

Figure 2

Expression of Mir221 and Mir222 in Mir221/222flox/y and Mir221/222AdipoKO male mice fed with high fat high sucrose (HFHS) or standard (STD) chow. (A, B) In various tissues, the expression of miR-221-3p and miR-222-3p is normalized by snoRNA202 and snoRNA234. The HFHS-induced up-regulation of miR-221-3p and miR-222-3p in epididymal adipose tissues was reversed in Mir221/222AdipoKO (red asterisks). (Epi, epididymal; Mes, mesenteric; Sub, inguinal; Brown, Brown adipose tissues) (C) Serum concentration of miR-221-3p and miR-222-3p. HFHS Mir221/222flox/y (n=3), HFHS Mir221/222AdipoKO (n=5), STD Mir221/222flox/y (n=5) and STD Mir221/222AdipoKO mice (n=6). Data shown as mean ± SD and analyzed by one-way ANOVA with Tukey test (*p<0.05; **p<0.01; ***p<0.001; ****p<0.0001).