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. 2022 Jan 3;12:799711. doi: 10.3389/fendo.2021.799711

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Copyright © 2022 Gorbatyuk, Pitale, Saltykova, Dorofeeva, Zhylkibayev, Athar, Fuchs, Samuels and Gorbatyuk

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sustained hyperglycemia resulted in compromised RGC function. (A) The PhNR amplitudes were reduced by 50% in the diabetic retina (right panel). (B) Images of the retinal flat mount processed with anti-BRN3A antibody (left panel). The number of BRN3A-positive RGCs in the diabetic retina was markedly reduced in zone 1, zone 2, and (zone-3 areas compared to the control group (right panel). See also Figure 4 for depicted area. (C) In agreement with the immunohistochemistry analysis, the expression of BRN3A protein was also diminished as detected by western blot analysis (representative membrane images on the left; calculated data on the right). **p < 0.01, ***p < 0.001, ****p < 0.0001, (n= 5-10).