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. 2022 Jan 3;12:763392. doi: 10.3389/fendo.2021.763392

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Copyright © 2022 Busby, Chen, Godfrey, Rehan, Wildman, Smith and Hassan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histone H3 modifications and RUNX2 binding on the promoter regions indicate the accessibility of Baf45 homolog promoters during Bone Marrow Stromal Cells (BMSCs) differentiation. Comparison of ChIP-Seq data acquired by Illumina sequencing. BMSCs were isolated from the bone marrow of mice, grown, and differentiated under osteogenic differentiation conditions, harvested at days 0, 7, 14, and 21, and ChIP-sequencing was performed. H3K27ac, H3K27me3, H3K9ac, H3K9me3, and RUNX2 antibodies were used to immunoprecipitate protein-DNA interactome (A) Genomic tracks display ChIP-seq data showing enrichment profiles for H3K27ac, H3K27me3, H3K9ac, H3K9me3, and RUNX2 at (A) Baf45a, (B) Baf45b, (C) Baf45c and (D) Baf45d gene promoters. Quantitative peaks representing active chromatin marks H3K9ac and H3K27ac and peaks representing repressive chromatin marks H3K9me3 and H3K27me3.