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. 2022 Jan 3;12:806740. doi: 10.3389/fgene.2021.806740

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Copyright © 2022 Zhang, Zhang and Min.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The transcription factors (TFs) and regulatory network involved in HS. (A) The differential transcriptional activities of the key TFs in FB-1 of HS samples. (B) The differential proportion of FB-1 cells expressing CREB3L1 and differential expression of TWIST2 between the FB1- cells of HS and NS. (C) The differential expression of TFs between the bulk RNA-seq samples of HS and NS. (D,E) Upregulation of TF target genes in the bulk RNA-seq samples of HS by gene set enrichment analysis (GSEA).