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. 2022 Jan 3;12:815160. doi: 10.3389/fgene.2021.815160

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Copyright © 2022 Liu, Xie, Wang, Liu, Zhu, Zou, Li, Wang, Leng, Xu, Yeh, Wang, Wen, Liu and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Manhattan showed the natural selection signatures and enrichment analysis. (A) p-values of XPEHH in the Miao population using northern Han as the reference population. (B) Overlap among three gene lists based on gene-level and shared-term level, where blue curves link genes that belong to the same enriched ontology term. The inner-circle represents gene lists, where hits are arranged along the arc. Genes that hit multiple lists are colored in dark orange, and genes unique to a list are shown in light orange. (C) Heatmap of top twenty enriched terms across three input gene lists, colored by p-values. (D) Top 20 clusters with their representative enriched terms. (E) Network of enriched terms colored by cluster-ID.