Table 2.
Clinical and biochemical characterization of T1DM participant with positive NGAL and negative NGAL.
| NGAL (+) n = 17 |
NGAL (−) n = 17 |
p-value | |
|---|---|---|---|
| Sex (male/female) | 10/7 | 8/9 | 0.730 |
| Age (years) | 15.60 ± 3.10 | 12.00 ± 5.50 | 0.030 |
| Age at Diagnostic (years) | 8.00 + 8.00 | 7.00 + 5.00 | 0.640 |
| T1DM evolution (years) | 6.60 + 5.40 | 4.34 + 3.10 | 0.030 |
| Z Height for age and sex | −0.34 ± 1.19 | −0.42 ± 0.64 | 0.980 |
| Z IMC for age and sex | 0.76 ± 0.83 | 0.55 ± 1.20 | 0.570 |
| Tanner stage 1 | 0 | 6 | 0.020 |
| 2 | 1 | 3 | 0.600 |
| 3 | 0 | 1 | 1.000 |
| 4 | 5 | 2 | 0.390 |
| 5 | 11 | 5 | 0.080 |
| SBP >p 95 | 4/17 | 2/17 | 0.660 |
| DBP >p 95 | 0 | 0 | 1.000 |
| MBP | 84.00 ± 9.81 | 78.00 ± 11.00 | 0.090 |
| HbA1c at enrollment (%) | 9.20 + 3.20 | 8.20 + 1.70 | 0.160 |
| Median of HbA1c one year before enrollment (%) | 8.80 ± 3.00 | 7.40 + 1.30 | 0.045 |
| Serum Creatinine (mg/dl) | 0.64 ± 0.10 | 0.52 ± 0.12 | 0.010 |
| MAU (mg/L) | 1.90 ± 10.60 | 1.50 ± 11.80 | 0.390 |
| ACR mg/g | 4.17 ± 6.75 | 1.90 ± 7.10 | 0.230 |
| GFR (ml/min/1.72 m2) | 162 ± 27 | 165 ± 21 | 0.620 |
| MAU >20 | 2/17 | 2/17 | 1.000 |
| ACR >30 | 2/17 | 0/17 | 0.490 |
| GFR >140 ml/min/m2 | 15/17 | 15/17 | 1.000 |
SBP, systolic blood pressure; DBP, diastolic blood pressure; MBP, mean blood pressure; HbA1c, glicosylated hemoglobin A1c; MAU, microalbuminuria; ACR, Albumin/creatinine urine ratio; GFR, glomerular filtration rate by modified Schwartz formula for children. Continuous variables are presented as median ± interquartile range (IQR). In the case of The Z height and Z BMI, the data are presented as mean ± SD. The Mann–Whitney test was used for all continuous variables, except for Z height and Z BMI in which t-test was used. The categorical variables are expressed as frequency and their analysis was used Fisher’s exact test. Bold values means differences are statistically significant (p < 0.05).