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. 2022 Jan 3;8:798353. doi: 10.3389/fmolb.2021.798353

FIGURE 11.

FIGURE 11

TM accessory subunits of the ND4 and ND5 interface. The structure of mammalian CI (PDB: 6ZKC throughout) in cartoon with the surface of (A) NDUFB11 (carrot orange), (B) NDUFB5 (cyan azure), and (C) NDUFB6 (old gold), the core subunits colored as in Figure 1A and the accessory subunits grey. (D) Lipid binding pocket in the mammalian ND4 (pearly purple)/ND5 (boysenberry purple) interface with the accessory subunits in cartoon and lipids in spheres. (E) Lipid binding in the Y. lipoyltica (PDB: 6YJ4) ND4/ND5 interface with the accessory subunits in cartoon and lipids in spheres. (F) The NDUFB11-S (short isoform) is shown in carrot orange cartoon. The additional 10 amino acids of the NDUFB11-L (long isoform, represented as dashed line) clash with core subunit ND4 but may be accommodated in the PD-a′ assembly with accessory subunits NDUFB6, NDUFB10 (vivid auburn) and NDUFB11 shown in cartoon. NDUFB11: carrot orange, NDUFB5: cyan azure, NDUFB6: old gold, ND4: pearly purple, ND5: boysenberry purple, NDUFB10: vivid auburn.