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. 2022 Jan 3;15:782490. doi: 10.3389/fnhum.2021.782490

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Copyright © 2022 Shu, Ding, Shang, Song, Lang and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Brain magnetic resonance imaging (MRI) findings in patients 1 and 2. Patient 1 (A–C) On admission, FLAIR hyperintensity was seen in the leptomeningeal of bilateral frontal lobe and parietal lobe in patient 1 (A) (arrowhead); repeat brain MRI FLAIR result returned to normal at discharge and 8 months after discharge (B,C). Patient 2 (D–G) Brain MRI results showed T2 FLAIR and DWI hyperintensity (D,E) (arrowhead) with swelling of brain tissue and narrowing of sulcus; the swelling of brain tissue was alleviated, and hyperintensity of FLAIR and DWI was improved after immunotherapy (F,G) (arrowhead); brain MRI normalized at 1 month after discharge (H).