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. 2022 Jan 3;12:751915. doi: 10.3389/fendo.2021.751915

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Copyright © 2022 Mancuso, Arato, Di Michele, Antognelli, Angelini, Bellucci, Lilli, Boncompagni, Fusella, Bartolini, Russo, Moretti, Nocchetti, Gambelunghe, Muzi, Baroni, Giovagnoli and Luca

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WB analysis. (A) Immunoblots of phosphoERK1-2/ERK1-2, phosphoJNK/JNK, phosphop38/p38, phosphoAKT/AKT, posphoNF-kB p65/NF-kB, and GAPDH in SCs 24 h and 1, 2, and 3 weeks of incubation with TiO₂ NPs 5 and 100 µg/ml. Densitometric analysis of the protein bands of phosphoERK1-2/ERK1-2 (B), phosphoJNK/JNK (C), phosphop38/p38 (D), phosphoAKT/AKT (E), and phosphoNF-kB p65/NF-kB (F) in SCs 24 h and 1, 2, and 3 weeks of incubation with TiO₂ NPs 5 (black bar) and 100 µg/ml (grey bar). Data represent the mean ± SEM (^* p < 0.05, ^** p < 0.001 vs. unexposed SCs (black dotted line) and ^# p < 0.05 vs. 5 µg/ml of TiO₂ NPs of three independent experiments, each performed in triplicate).