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. 2022 Jan 3;9:781848. doi: 10.3389/fcell.2021.781848

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Copyright © 2022 Yao, Li and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation of the BC subtyping method in a single-cell RNA-seq dataset. (A) Hierarchical clustering of 317 tumor cells from ten BC patients based on the enrichment scores of four immune-related pathways. (B) Comparisons of the expression levels of 19 human leukocyte antigen (HLA) genes among the subtypes. One-way analysis of variance (ANOVA) test p values are shown. (C) Comparisons of proportions of TNBC, HER2+, and ER + tumor cells among the subtypes. The Fisher’s exact test p values are shown.