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. 2022 Jan 3;15:725195. doi: 10.3389/fncel.2021.725195

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Copyright © 2022 Olmsted, Stigliano, Marzullo, Cibelli, Horner and Paluh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OPCs thrive and morphologically develop in the contusion injury site. (A) Mature oligodendrocyte marker APC and transplanted GFP-OPCs at 10 days and 6 weeks time points, counterstained with DAPI. (B) GFP-OPCs increase in morphological complexity over 6 weeks in association with SOX10+ cells in the contusion injury microenvironment. Ten days and 6 weeks time points shown with DAPI. (C) GFP-OPCs survive and integrate within the GFAP+ injury milieu by 6 weeks. (D) GFP-OPCs arborize in the contusion injury microenvironment. O4 staining shown with DAPI. (E,F) Analysis of GFP-OPC and GFAP signal overlap at 6 weeks. GFAP and GFP signal is distinct with regions of overlap along STEM121 neural processes. Two examples are provided with zoom images. Asterisks depict GFP-OPC (green), GFAP (magenta), STEM121 (red), and signal overlap (white). R (rostral), C (caudal). Individual scale bars are provided.