Fig. 3.

Granulation tissue developed in the abdominal-muscle wall excision model. A: Representative cross-sectioned granulation tissues developed for 21 days (Masson’s trichrome (MT) stain). The granulation tissue changed from a zonal structure (day 7) to a wavy nodular/spherical-like structure (days 14 and 21). Bars=100 μm. B: The collagenous area in the MT stain was measured in granulation tissues for 21 days after tissue excision. **: P<0.01. C: Representative images of CD31 and α-SMA in granulation tissue on day 14. CD31-positive vessels in the circular area are indicated by arrows. α-SMA-positive cells are distributed zonally between parentheses, and vessel walls are also positive for α-SMA (arrows). Bars=100 μm.