Developed and residual scar lesions in the abdominal wall model. A:
Multi-nodular/spherical-like structured lesions in the abdominal wall model
developed on day 21. B: The scar lesion on day 21 shows massive
collagen deposition, which is hazy and hyalinized in hematoxylin and eosin staining.
C: Picrosirius red staining: The fibrous lesion that developed in the
abdominal wall model forms a storiform pattern (left), in which thick collagen
bundles are primarily stained in orange color, showing type 1 collagen. In the back
skin splint model (right), thin collagen bundles were deposited in the granulation
tissue on day 21, many of which were stained green, showing type 3 collagen.
D: In the abdominal wall model, an apparent collagen-rich scar lesion
(arrows) remained after 87 days of the study, which was deformed and different from
that in the normal control in a similar tissue site (left).