Table 2.
Differences in miRNA levels detected in the NAFLD-only sequencing analysis.
| miRNA | logFC | logFC SE | Adj. p val.∗ |
|---|---|---|---|
| NASH grouped relative to NAFL | |||
| miR-193a-5p | 0.49 | 0.11 | 3.70E-03 |
| miR-378d | 0.37 | 0.09 | 4.97E-03 |
| miR-378e | 0.35 | 0.09 | 1.01E-02 |
| miR-4484 | 0.35 | 0.09 | 2.05E-02 |
| NASH with significant fibrosis (F2–F4) relative to NAFL/NASH with minimal fibrosis (F0/F1) | |||
| miR-193a-5p | 0.43 | 0.10 | 1.79E-03 |
| miR-378e | 0.34 | 0.07 | 1.79E-03 |
| miR-378d | 0.33 | 0.07 | 1.85E-03 |
| High NAS (NAS 5–8) relative to low NAS (NAS 1–4) | |||
| miR-193a-5p | 0.44 | 0.09 | 2.61E-04 |
| miR-378d | 0.29 | 0.07 | 7.14E-03 |
| miR-320d | 0.32 | 0.09 | 2.39E-02 |
| miR-378e | 0.26 | 0.07 | 2.39E-02 |
| miR-320b | 0.32 | 0.09 | 2.89E-02 |
| miR-320c | 0.32 | 0.09 | 2.89E-02 |
| miR-320e | 0.29 | 0.08 | 2.89E-02 |
| High SAF activity (SAF activity 3–4) relative to low SAF activity (SAF activity 0–2) | |||
| miR-193a-5p | 0.43 | 0.11 | 2.70E-02 |
| miR-378d | 0.34 | 0.09 | 2.70E-02 |
| miR-378e | 0.34 | 0.09 | 2.70E-02 |
| miR-19b-3p | -0.74 | 0.20 | 2.73E-02 |
Adj. p val., adjusted p value; logFC, log2 fold change; miRNA, microRNA; NAFL, non-alcoholic fatty liver; NAFLD, non-alcoholic fatty liver disease; NAS, NAFLD activity score; NASH, non-alcoholic steatohepatitis; SAF, steatosis–activity–fibrosis.
∗
Adjusted p value significance threshold ≤0.05.