Skip to main content
. 2021 Nov 29;41(2):e108591. doi: 10.15252/embj.2021108591

Figure 2. Aβ binding to APR homologues derived from human proteins.

Figure 2

  • A
    Sequence similarity in combination with peptide length for 1,000 random proteins derived from human proteome. Graph: bottom and top of the boxes are the first and third quartiles, central band represents median, whiskers encompass minimum and maximum.
  • B, C
    Distribution of amino acids in homologues to Aβ KLVFFA (B) and LVFFAE (C) proteins.
  • D
    Binding of Biot‐Aβ1‐42 to homologue peptides derived from ˜ 520 randomly selected proteins.
  • E
    Summary of Biot‐Aβ1‐42 binding throughout eight membranes, colour indicates the mean between membranes and the size of the outline of the standard deviation.
  • F
    Heatmap of amino acid substitutions in membrane hits.
  • G, H
    Membrane top binders spell AD and PLAK, white space consists of random sequences. (sequences in Appendix Table S2).