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. Author manuscript; available in PMC: 2022 Jan 17.
Published in final edited form as: J Am Chem Soc. 2021 Jul 2;143(27):10462–10476. doi: 10.1021/jacs.1c05470

Scheme 1.

Scheme 1.

Synthesis of Pre-LS-4 and LS-4a

a(a) SnCl2, conc. HCl, EtOH, reflux, 3 h; (b) (CH2O)n, NaBH3CN, CH3COOH, room temperature, overnight; (c) 2-methoxy-4-vinylphenol, Pd(OAc)2, triethanolamine, 100 °C, 24 h; (d) Me2HTACN, (CH2O)n, MeCN, reflux, 24 h.