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. 2021 Dec 15;65(1):409–423. doi: 10.1021/acs.jmedchem.1c01586

Figure 2.

Figure 2

Dose response curves for compounds 1, 6, and 12 tested against H37Rv and a strain where pks13 gene expression is regulated by the TetON promoter. Growth in the presence of anhydrotetracycline (ATc) results in modest transcriptional overexpression of pks13 while removal of ATc results in transcriptional repression of pks13 expression. Growth in the presence of negative control (rifampicin), 1, 6, and 12 are shown relative to DMSO-treated samples. Data are representative of two independent experiments.