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(A) Brain endothelial cells form the cellular barrier and are connected continuously by the means of tight junctions; tight junctions are the main structures of the blood–brain barrier and selectively transfer nutrients between the blood and the brain. The role of the pericytes is controlling the cerebral blood flow while astrocyte end feet are responsible for biochemical support of the endothelial cells.122 (B) Various strategies for diffusion through the blood–brain barrier.127
