Table 2.
Clinical and Genetic Characteristics of the Three Perimetric Groups With Occult Macular Dystrophy
| Characteristics | Central Scotoma (n = 54) | Other Scotomata (n = 14) | No Scotoma (n = 8) | P Value |
|---|---|---|---|---|
| Age, y | 45.8 ± 17.6 (17–79) | 68.0 ± 16.3 (27–86) | 56.0 ± 11.8 (39–68) | <0.001 |
| Sex, male:female | 36 (66.7%):18 (33.3%) | 6 (42.9%):8 (57.1%) | 4 (50%):4 (50%) | 0.200 |
| Age of onset, y | 24.0 ± 15.0 (2–60) | 53.4 ± 16.5 (14–73) | 45.0 ± 16.2 (22–62) | <0.001 |
| Disease duration, y | 21.9 ± 14.4 (5–65) | 14.6 ± 7.9 (5–28) | 11.7 ± 4.6 (6–16) | 0.045 |
| Best-corrected visual acuity, logMAR | 0.666 ± 0.254 (0.15–1.22) | 0.369 ± 0.375 (–0.08–1.00) | 0.094 ± 0.199 (–0.08–0.40) | <0.001 |
| Symptomatic (%) | 54 (100%) | 12 (85.7%) | 4 (50%) | <0.001 |
| p.R45W as pathogenic variants (%) | 39 (72.2%) | 5 (35.7%) | 2 (25%) | 0.004 |
| Mean deviation, dB | ||||
| 10-2 | –2.35 ± 1.93 (–6.33–0.09) | –4.44 ± 4.79 (–11.25––0.91) | –0.50 ± 1.00 (–2.81–0.46) | 0.032 |
| 30-2 | –2.97 ± 2.56 (–11.22 to –0.35) | –3.68 ± 2.35 (–6.03 to –0.63) | N/A | 0.498 |
| Pattern standard deviation, dB | ||||
| 10-2 | 2.05 ± 0.57 (1.46–3.13) | 3.80 ± 3.51 (1.17–8.73) | 1.14 ± 0.13 (0.97–1.38) | 0.013 |
| 30-2 | 3.84 ± 1.77 (2.07–9.96) | 3.24 ± 0.86 (2.31–5.06) | N/A | 0.368 |
| Degree | 0 degrees to 5 degrees (n = 26, 48.1%), 0 degrees to 10 degrees (n = 23, 42.6%), 0 degrees to 20 degrees (n = 5, 9.3%) | 5 degrees to 15 degrees (n = 6, 46.2%), 0 degrees to 20 degrees (n = 5, 38.5%), 0 degrees to 10 degrees (n = 2, 15.4%) | N/A | N/A |
N/A, not applicable.