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. Author manuscript; available in PMC: 2022 Jan 17.
Published in final edited form as: Anal Chem. 2021 Jul 27;93(31):10879–10889. doi: 10.1021/acs.analchem.1c01246

Figure 1.

Figure 1.

(a) Single quadrupole MS quantitive analysis general experimental design. (b) Fragment ion intensity ratio for enhanced in-source multiple fragment ion monitoring single quadrupole and MRM triple quadrupole comparison between electrospray ionization positive mode and negative mode. (c) Fragment ion intensity ratio comparison between lipids/fatty acids and other molecules. Log transformed intensity ratio was used in (b) and (c). (d) A typical extracted ion chromatogram of a single quadrupole channel (xanthine in solvent, fragment ion 108 at RT 2.80 min). (e) A typical extracted ion chromatogram of a triple quadrupole transition (xanthine in solvent, transition 151>108 at RT 2.84 min). The number next to the single quadrupole channel or triple quadrupole transition in (d) and (e) represents the maximum intensity of the EIC.