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. 2021 Dec 9;13(1):38–49. doi: 10.1021/acsmedchemlett.1c00526

Figure 3.

Figure 3

(A) Administration of 5 inhibits serum AFP secretion in vivo. Mice were treated for 27 days, 3 times a week, starting 3 weeks following HCC transplantation with two doses of 1 (0.1 mg/kg [2 μg], green bars or 1 mg/kg [20 μg], red bars), compared with untreated controls (blue bars). Levels are normalized to the starting day of therapy. (B) Compound 5 diminishes tumor volume in both treated groups (0.1 mg/kg [2 μg], green bars and 1.0 mg/kg [20 μg], red bars) compared to untreated controls (blue bars). Figure reproduced from ref (35). Copyright 2015 American Chemical Society.