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. 2022 Jan 17;29:3. doi: 10.1186/s12929-022-00787-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Sex dependence of lung cancer progression in a gender-dependent manner. Cancer formation was induced by water (RO-Male) or doxycycline (Dox-Male and Dox-Female) treatment for 1.5 months in mice with EGFR^L858R-induced lung cancer mice. Cancer formation in the lung was studied by H&E staining, thus the lung area was quantitated by ImageJ software and listed on the left side (A). The tumor burden in 17 male mice (Dox-Male) and 25 female mice (Dox-Female) was quantitated by subtracting the lung area of normal mice (RO-mice), and statistically analyzed by a t test; *p < 0.05 (B). Female mice with EGFR^L858R-induced lung cancer were treated with 10 mg/kg tamoxifen (TAM), intraperitoneal injection and one time every week to study the survival rate with Kaplan–Meier survival curves (C). Tumor formation in the lungs of EGFR^L858R mice (14 weeks of age) with or without ovary removal was studied by H&E staining including ×10 (D, (a)) and ×40 (D, (b)) images, and measurement of the axis length of lung size and statistically analyzed by a t test; *p < 0.05 (D, (c))