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. 2022 Jan 17;41:26. doi: 10.1186/s13046-022-02245-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Mutant SF3B1 altered DLG1 expression. ADLG1 mRNA expression (RNA-seq data and quantitative PCR) in SF3B1 mutant (n = 2) vs. wild-type (n = 13) human prolactinoma tumors. BDLG1 mRNA expression in Sf3b1 mutant (n = 3) versus wild-type (n = 3) GH3 cells. FPKM: Fragments per kilobase per million mapped fragments. The results are expressed as mean ± SD (Student’s t test, *P < 0.05, ****P < 0.0001). C Representative immunohistochemical staining for DLG1 in SF3B1 mutant and wild-type human prolactinoma tumors; scale bar: 50 μm. D Immunofluorescence staining for DLG1 in rat prolactinoma tumors stereotactically injected with Ad-null, Ad-SF3B1^WT, and Ad-SF3B1^R625H, respectively; scale bar: 50 μm