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. 2022 Jan 15;19(1):74–89. doi: 10.20892/j.issn.2095-3941.2020.0218

Table 1.

Cytotoxicity of dextromethorphan, tetracycline, nifedipine, atorvastatin, and nortriptyline against the respective cancer cell lines (n = 3)

Drug Cancer type Rank (%) Cell line IC50 (µM)
Dextromethorphan HBr monohydrate Breast cancer Top 2.64 MCF-7 71.52 ± 1.84
MDA231-LM2-4175 95.83 ± 28.03
Tetracycline hydrochloride Prostate cancer Top 0.15 LNCaP 13.79 ± 4.50
DU145 35.35 ± 14.37
Gastric cancer Top 0.20 MGC-803 46.86 ± 11.65
Nifedipine Prostate cancer Top 1.00 LNCaP 14.69 ± 2.89
DU145 26.66 ± 19.26
Gastric cancer Top 1.25 MGC-803 20.73 ± 10.10
Atorvastatin calcium Gastric cancer Top 0.39 MGC-803 4.60 ± 1.69
Nortriptyline hydrochloride Prostate cancer Top 0.02 LNCaP 18.71 ± 3.48
DU145 23.81 ± 7.51
Metformin Breast cancer Top 0.15 MCF-7 11.11 × 103–33.33 × 103
MDA231-LM2-4175 11.11 × 103–33.33 × 103
Prostate cancer Top 0.17 DU145 3.7 × 103–11.11 × 103
LNCaP ~6.58 × 103
Gastric cancer Top 0.02 MGC-803 3.7 × 103–11.11 × 103

IC50 represents the mean ± standard deviation.