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. 2022 Jan 15;19(1):90–103. doi: 10.20892/j.issn.2095-3941.2020.0313

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Copyright: © 2022, Cancer Biology & Medicine

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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PCSK9 promotes dissociation of GSTP1 dimers and activity of the JNK signaling pathway. (A) GSTP1 expression and JNK signaling pathway activity were detected by Western blot. (B) The abundance of GSTP1 dimers in 97H cells was detected under nonreducing conditions. (C) The ability of GSTP1 to bind to JNK was evaluated by co-immunoprecipitation. (D) The effect of PCSK9 on JNK pathway activity was significantly inhibited by siGSTP1. (E) The effect of PCSK9 on HCC growth inhibition was decreased by siGSTP1. *P < 0.05; **P < 0.01.