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SNORA23 impairs ribosome biogenesis by affecting 4EBP1 phosphorylation. (A) The phosphorylation level of 4EBP1 was inhibited in SNORA23-overexpressing and promoted in SNORA23 knockout Huh7 cells. (B) The ribosomal biological activity was measured by O-oropargyl-puromycin staining in SNORA23-overexpressing, SNORA23 knockout, and control Huh7 cells. Scale bars: 20 µm.
