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. Author manuscript; available in PMC: 2022 May 9.
Published in final edited form as: Sci Signal. 2021 Nov 9;14(708):eabg2648. doi: 10.1126/scisignal.abg2648

Fig. 2. Ischemic neonatal seizures in P10 CD1 pups were phenobarbital responsive.

Fig. 2.

(A) Doses and treatment protocols to evaluate CLP290 in P10 CD-1 pups. (B) Representative EEG traces and seizure frequency raster plots of a P10 phenobarbital-only and CLP290 10’ pup. Black bars represent a loading dose of PB (25 mg/kg i.p.). (C) 1st- and 2nd-hour percent seizure suppression at P10 after unilateral carotid ligation. Percent seizure suppression was analyzed by one-way ANOVA vs. PB-only. PB-only; n=13; CLP290 10 n=7; CLP290 20 n=8; CLP290 10’ n=12; CLP290 20” n=8 pups. For 1st- and 2nd-hour seizure burden and ictal events, see fig. S1.