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Meiotic chromosomes are organized as an array of loops anchored to an axis (including cohesins, Hop1, and Red1). (Left panel) The ZMM proteins (Zip4, Zip2, Spo16, Msh4, Msh5, Zip3, Zip1, and Mer3) channel DSB repair toward the homolog and stabilize the D-loop intermediate. (Right panel) Zip4, by recruiting Ecm11 and Gmc2, is promoting synapsis initiation with the loading of Zip1 and other structural proteins, then elongating along the axis.
