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. 2022 Jan 1;36(1-2):84–102. doi: 10.1101/gad.348782.121

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© 2022 Hada et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — The THDs construct stable B compartment domains. (A) IGV snapshot showing the A/B compartments from Hi-C analysis and early/late replication timing from Repli-seq. Light-magenta areas indicate overlapped regions of THDs and the lowest 20 percentile of Hi-C PC1 values in TSCs. d0 and d7 CBMS1 ESCs represent the statuses of undifferentiated ESCs and differentiated ESCs for neurectoderm (7 d after differentiation), respectively. Hi-C and Repli-seq data for ESCs were obtained from Miura et al. (2019). (B) Heat map showing average contact enrichment between pairs of 200-kb bins sorted by their Hi-C PC1 values, from the lowest (the most extreme B) to the highest (the most extreme A). Names of cells, time points of ESC differentiation, and the scale bar of observed/expected ratio are as indicated. (C) Bar plots showing the differential ratio of B–B/A–B (left) and A–A/A–B (right) interactions between each cell and d0 ESCs. Note that TSCs show strong B–B compartment interaction as well as A–A compartment interaction.