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. 2022 Jan 1;36(1-2):84–102. doi: 10.1101/gad.348782.121

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© 2022 Hada et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 5. — TSCs and the extraembryonic linage share the H3K9me3 domains, which originate from preimplantation embryos. (A) IGV snapshots showing enrichment of H3K9me3 in ESCs, TSCs, preimplantation embryos, and postimplantation embryos. H3K9me3 ChIP-seq data against preimplantation and postimplantation embryos were obtained from Wang et al. (2018). The light-magenta area indicates a THD that seems to be inherited from preimplantation embryos by the extraembryonic tissues (ExE). (TE) Trophectoderm, (ICM) inner cell mass, (Epi) epiblast, (ExE) extraembryonic ectoderm. (B) Heat map showing H3K9me3 dynamics of the H3K9me3 domains defined by either E7.5 Epi or ExE. The domains are classified into five clusters by their pattern before and after implantation. The number of domains in each cluster is indicated in parenthesis. (C) Bar plot showing the distribution of the domains over 0.3 Mb among the clusters. (D) Violin plot showing the LINE/L1 density in each cluster. P-values from the Wilcoxon rank-sum test are indicated.