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. 2022 Jan 1;36(1-2):53–69. doi: 10.1101/gad.348973.121

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© 2022 Pyatnitskaya et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 7. — Model for the link between crossover sites and SC assembly. The model is based on our study of Zip4–Ecm11 interaction and published studies (see the text). (1) First, the axial element polymerizes, and ZZS is recruited to the axis after DSB formation. (2) Then SICs are formed after the transition of ZMMs (including ZZS) to the interaxis region. the Ecm11–Gmc2 heterodimer is brought to the SIC through its interaction with Zip4, which initiates the polymerization of the TF Zip1. Polymerization of the SC central region inhibits the formation of de novo DSBs, thus avoiding additional break and repair in already synapsed regions.